Mildronate can be used as doping substances are abused and prohibited in professional sports since 1 January 2016th In March 2016 it was announced that the tennis player Maria Sharapova was tested positive in a doping test at the Australian Open. She had taken the funds for ten years and was apparently unaware that it was forbidden since the beginning of the year. In sports Meldonium may inter alia promote endurance, improve recovery and increase mental capacity. Besides Maria Sharapova other athletes tested positive at the beginning of the year.
Mildronate has anti-ischemic properties. The effects of inhibition of carnitine biosynthesis attributed by inhibiting the enzyme γ-butyrobetaine hydroxylase. This Meldonium reduces the breakdown of fatty acids in ischemic tissue (β-oxidation) and it is more glucose consumed. Consequently toxic intermediates are less educated and less oxygen is consumed. In addition, other mechanisms play a role. click here for more.
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